Bruno Mussolini was born in Milan in Lombardy. His father, Benito Mussolini, was the editor of "The People of Italy" (Il Popolo d'Italia) newspaper before Bruno's birth and, on 22 April 1918, was away for the day in Genoa. Mussolini indicated to his wife that he did not want her to give birth before his return. In his words: "I don't want to be the last to be told again, as I was with Vittorio." That evening, the manager of the newspaper greeted Mussolini at the station with a broad grin and the words: "It's a boy."
In 1919, Bruno Mussolini caught diphtheria and his parents feared he would never recover. Soon after the doctors pronounced him out of danger, he suffered from a bronchial complaint. By this time, one-year-old Bruno's weight had dropped to about 15 pounds (6.8 kg).
As a young student, 9-year-old Bruno adeptly, if not correctly, answered a schoolteacher's question about grammar. An examiner is reported to have said: "Now Bruno, tell me what person one cannot command." In response, Bruno tactfully responded: "There are two persons one cannot command, the King and my father."
On 7 November 1938, Bruno married Gina Ruberti [nb 1] in Rome.[nb 2] His wife was the daughter of the head of the Ministry of Education's Contemporary Art Bureau. On 18 March 1940 in Rome, Bruno and his wife had their first child, a daughter, named Mariana.
In 1935, Bruno Mussolini joined the Royal Italian Air Force (Regia Aeronautica Italiana) and became a pilot. He flew for the Regia Aeronautica during the Second Italo-Ethiopian War. In September, before the Kingdom of Italy invaded the Ethiopian Empire, Air Sergeant Bruno Mussolini, 17, Air Second Lieutenant Vittorio Mussolini, 18, and Air Captain Count Nobile Galeazzo Ciano, 32, sailed from Naples to Africa aboard the MS Saturnia. After Ethiopia, Bruno also participated in the Spanish Civil War and World War II. Unlike his brother Vittorio, Bruno was considered to be a serious pilot. In addition to participating in various conflicts, Bruno was involved in setting flight airspeed records in a 1938 flight to Brazil.
On 7 August 1941, the 23-year-old Mussolini, commander of the 274a Squadriglia (274th Squadron), was flying in one of the prototypes of the "secret" Piaggio P.108B bomber, MM22003, near the San Giusto Airport in Pisa, when the aircraft flew too low and crashed into a house. The cockpit section was separated from the rest of the aircraft and Bruno Mussolini died of his injuries. The machine did not catch fire but was nevertheless totally destroyed in the impact. Five members of the crew were injured and three died, including Bruno. Benito Mussolini rushed to the Santa Chiara Hospital to be at the side of his dead son.
Bruno's death prompted his father to compose a booklet entitled "I Talk With Bruno" (Parlo con Bruno). The booklet implied timeless intimacy between the two and mixed Fascist, Catholic, and familial piety. 
- Benito Albino Mussolini – Bruno Mussolini's older half brother
- Vittorio Mussolini – Bruno Mussolini's older brother
- Romano Mussolini – Bruno Mussolini's younger brother
- István Horthy – son of Hungarian Regent Admiral Miklós Horthy, also died in an aircraft-related incident
- Edda Mussolini - Bruno Mussolini's older sister
- Mussolini/Zarca, Mussolini, p. 26
- Mussolini/Zarca, Mussolini, p. 40
- Time Magazine, Smart Bruno
- Time Magazine, Journalism is Life
- Bosworth, p.345
- Time Magazine,Bruno's Last Flight
- Time Magazine,With, Without or Against
- Time Magazine, Down in Flames
- Bignozzi 1986, p. 305
- Time Magazine,Bruno's Last Flight
- Bosworth, p. 346
- Miki Turner (18 November 2000). "'Ally' Creator Hopes Downey Jr. Helps Ratings". Chicago Tribune. Retrieved 15 September 2014.
- Bignozzi, Giorgio. "The Italian 'Fortress' (part 1)." Air International Vol. 31 No. 6, December 1986. p. 298-305, (part 2). Air International Vol. 32 No. 1, January 1987. p. 29-31, p. 47-49.
- Bosworth, R.J.B. (2005). Mussolini's Italy: Life Under the Fascist Dictatorship, 1915-1945. New York: Penguin Press. p. 692. ISBN 1-59420-078-5.
- Musolini, Rachele (1974). Mussolini: An Intimate Biography by His Widow (as told to Albert Zarca). New York: William Morrow. p. 291. ISBN 0-688-00266-8.