Abbreviated title (ISO 4)
|Edited by||Richard Horton|
The Lancet was founded in 1823 by Thomas Wakley, an English surgeon who named it after the surgical instrument called a lancet, as well as after the architectural term "lancet arch", a window with a sharp pointed arch, to indicate the "light of wisdom" or "to let in light".
The Lancet publishes original research articles, review articles ("seminars" and "reviews"), editorials, book reviews, correspondence, as well as news features and case reports. The Lancet has been owned by Elsevier since 1991. As of 2015[update], the editor-in-chief is Richard Horton. The journal has editorial offices in London, New York, and Beijing.
- 1 Impact
- 2 Specialty journals
- 3 Volume renumbering
- 4 Controversies
- 4.1 Autism and vaccine controversy (1998)
- 4.2 Tobacco control (2003)
- 4.3 Iraq War death toll controversy (2004)
- 4.4 Fabricated articles withdrawn (2006)
- 4.5 Dispute with the Vatican about condoms and AIDS prevention (2009)
- 4.6 India and superbugs (2010)
- 4.7 Health impact of alcohol (2010)
- 4.8 PACE study (2011)
- 4.9 Open Letter for the People of Gaza (2014)
- 5 List of editors
- 6 See also
- 7 References
- 8 External links
The Lancet also publishes several specialty journals: The Lancet Neurology (neurology), The Lancet Oncology (oncology), The Lancet Infectious Diseases (infectious diseases), The Lancet Respiratory Medicine (respiratory medicine), The Lancet Psychiatry (psychiatry), The Lancet Diabetes and Endocrinology (endocrinology), and The Lancet Gastroenterology & Hepatology (Gastroenterology) all of which publish original research and reviews. In 2013, The Lancet Global Health (global health) became the group's first fully open access journal. In 2014, The Lancet Haematology (haematology) and The Lancet HIV (infectious diseases) were launched, both as online only research titles. In 2017, The Lancet Child & Adolescent Health (paediatrics) will launch. The three established specialty journals (The Lancet Neurology, The Lancet Oncology, and The Lancet Infectious Diseases) have built up strong reputations in their medical specialty. According to the 2013 Journal Citation Reports by Thomson Reuters, The Lancet Neurology's impact factor is 22, The Lancet Oncology 25, and The Lancet Infectious Diseases 20. There is also an online website for students entitled The Lancet Student in blog format, launched in 2007.
Prior to 1990, The Lancet had volume numbering that reset every year. Issues in January to June were in volume i, with the rest in volume ii. In 1990, the journal moved to a sequential volume numbering scheme, with two volumes per year. Volumes were retro-actively assigned to the years prior to 1990, with the first issue of 1990 being assigned volume 335, and the last issue of 1989 assigned volume 334. The table of contents listing on ScienceDirect uses this new numbering scheme.
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The Lancet has taken a political stand on several important medical and non-medical issues. Recent examples include criticism of the World Health Organization (WHO), rejection of the WHO's claims of the efficacy of homoeopathy as a therapeutic option, disapproval during the time Reed Exhibitions (a division of Reed Elsevier) hosted arms industry fairs, a call in 2003 for tobacco to be made illegal, and a call for an independent investigation into the American bombing of a hospital in Afghanistan in 2015.
The Lancet was criticized after it published a paper in 1998 in which the authors suggested a link between the MMR vaccine and autism. In February 2004, The Lancet published a statement by 10 of the paper's 13 coauthors repudiating the possibility that MMR could cause autism. The editor-in-chief, Richard Horton, went on the record to say the paper had "fatal conflicts of interest" because the study's lead author, Andrew Wakefield, had a serious conflict of interest that he had not declared to The Lancet. The journal completely retracted the paper on 2 February 2010, after Wakefield was found to have acted unethically in conducting the research.
The Lancet's six editors, including the editor-in-chief, were also criticized in 2011 because they had "covered up" the "Wakefield concocted fear of MMR" with an "avalanche of denials" in 2004.
A December 2003 editorial by the journal, titled "How do you sleep at night, Mr Blair?", called for tobacco use to be completely banned in the UK. The Royal College of Physicians rejected their argument. John Britton, chairman of the college's tobacco advisory group, praised the journal for discussing the health problem, but he concluded that a "ban on tobacco would be a nightmare." Amanda Sandford, spokesperson for the anti-tobacco group Action on Smoking and Health, stated that criminalizing a behaviour 26% of the population commit "is ludicrous." She also said: "We can't turn the clock back. If tobacco were banned we would have 13 million people desperately craving a drug that they would not be able to get." The deputy editor of The Lancet responded to the criticism by arguing that no other measures besides a total ban would likely be able to reduce tobacco use.
The smokers rights group FOREST stated that the editorial gave them "amusement and disbelief". Director Simon Clark called the journal "fascist" and argued that it is hypocritical to ban tobacco while allowing unhealthy junk foods, alcohol consumption, and participation in extreme sports. Health Secretary John Reid reiterated that his government is committed to helping people give up smoking. He added: "Despite the fact that this is a serious problem, it is a little bit extreme for us in Britain to start locking people up because they have an ounce of tobacco somewhere."
The Lancet also published a controversial estimate of the Iraq War's Iraqi death toll—around 100,000—in 2004. In 2006, a follow-up study by the same team suggested that the violent death rate in Iraq was not only consistent with the earlier estimate, but had increased considerably in the intervening period (see Lancet surveys of casualties of the Iraq War). The second survey estimated that there had been 654,965 excess Iraqi deaths as a consequence of the war. The 95% confidence interval was 392,979 to 942,636. 1,849 households that contained 12,801 people were surveyed.
The estimates provided in the second article are much higher than those published in other surveys from the same time. Most notably, the "Iraq Family Health Survey" published in the New England Journal of Medicine surveyed 9,345 households across Iraq and estimated 151,000 deaths due to violence (95% uncertainty range, 104,000 to 223,000) over the same period covered in the second Lancet survey by Burnham et al. The NEJM article stated that the second Lancet survey "considerably overestimated the number of violent deaths" and said the Lancet results were "highly improbable, given the internal and external consistency of the data and the much larger sample size and quality-control measures taken in the implementation of the IFHS."
In January 2006, it was revealed that data had been fabricated in an article by the Norwegian cancer researcher Jon Sudbø and 13 co-authors published in The Lancet in October 2005. Several articles in other scientific journals were withdrawn following the withdrawal in The Lancet. Within a week, the New England Journal of Medicine published an expression of editorial concern regarding its published research papers by the same author, and in November 2006 the journal withdrew two oral cancer studies led by the Norwegian researcher.
In a 2009 editorial, the journal accused Pope Benedict XVI of publicly distorting scientific evidence on condoms to promote Catholic doctrine on chastity in AIDS prevention. The Vatican defended itself by pointing to an earlier Lancet article published in 2000 which asserted that condoms could not possibly be sufficient in solving the AIDS crisis.
In August 2010, The Lancet Infectious Diseases published an article about an enzyme conferring multi-drug-resistance properties in bacteria, which had previously been named New Delhi metallo-beta-lactamase or NDM-1 based on the assumed origin of the mechanism. The article reported 44 clinical isolates of bacteria positive for NDM-1 from Chennai, 26 from Haryana, 37 (from 29 patients) from the UK, and 73 from other sites in India, Pakistan, and Bangladesh. Of the 29 UK patients, 17 had a history of travel to India or Pakistan within 1 year, and 14 had been admitted to hospital in these countries. The authors of the article cited medical tourism to India for the spread of bacteria carrying NDM-1, which the Indian government denied.
A December 2010 article determined that alcohol had the worst medical and social effects compared to other recreational substances such as heroin and crack cocaine. The drugs marijuana, ecstasy, and LSD scored far lower in terms of related harms. The authors did not advocate alcohol prohibition, but they suggested that the government raise the price of alcohol until it was no longer widely available. Gavin Partington, spokesman of the Wine and Spirit Trade Association, responded to the report by saying that alcohol abuse affects "a minority" who needs "education, treatment and enforcement". He also remarked that millions of British citizens enjoy alcohol as "a regular and enjoyable social drink".
In 2011, The Lancet published a study by the UK-based "PACE trial management group", which reported success of a combination of exercise and talk therapy for chronic fatigue syndrome; a follow-up study was published in Lancet Pyschiatry in 2015. The study has been highly controversial; for example, biostatistician Bruce Levin of Columbia University described the study as "the height of clinical trial amateurism," and Ronald Davis of Stanford University wrote, “I’m shocked that the Lancet published it…The PACE study has so many flaws and there are so many questions you’d want to ask about it that I don’t understand how it got through any kind of peer review.”
Controversy has arisen not just from the published papers but also with the authors' refusal to share data from the study: "Starting in 2011, patients analyzing the study filed Freedom of Information Act requests to learn what the trial’s results would have been under the original protocol. Those were denied along with many other requests about the trial, some on the grounds that the requests were 'vexatious.' The investigators said they considered the requests to be harassment. . . . Richard Horton, the editor of the Lancet, aggressively defended the trial. In a radio interview, he called the critics 'a fairly small, but highly organized, very vocal and very damaging group of individuals who have, I would say, actually hijacked this agenda and distorted the debate so that it actually harms the overwhelming majority of patients.'".
In 2016 an Information Tribunal ordered the release of some of the PACE trial's data. This data allowed for the calculation of results for the trials pre-specified recovery criteria, which showed that additional treatment led to no significant improvement in recovery rates over the control condition, with all four the the trial's groups showing recovery rates under 8%. In contrast, a commentary published by the Lancet in 2011 had claimed that "the recovery rate of cognitive behaviour therapy and graded exercise therapy was about 30%".
In August 2014, The Lancet published an "Open letter for the people of Gaza" in their correspondence section. As reported in the Daily Telegraph, the letter "condemned Israel in the strongest possible terms, but strikingly made no mention of Hamas' atrocities." The authors of the letter include doctors who "are apparently sympathetic to the views of David Duke, a white supremacist and former Ku Klux Klan Grand Wizard." One of the doctors responded by saying: "I legitimately use my right of freedom of opinion and do not agree or value the politics of the government of Israel, nor of many others, including Jews in and out of Israel." A second one responded with: "I didn't know who David Duke was, or that he was connected to the Ku Klux Klan. I am concerned that if there is any truth in the video, that Jews control the media, politics and banking, what on earth is going on? I was worried."
The editor of the Lancet, Richard Horton, said: "I have no plans to retract the letter, and I would not retract the letter even if it was found to be substantiated.” However, Horton subsequently came to Israel's Rambam Hospital for a visit and said that he "deeply, deeply regrets" publishing the letter.
Mark Pepys wrote: “The failure of the Menduca et al authors to disclose their extraordinary conflicts of interest… are the most serious, unprofessional and unethical errors. The transparent effort to conceal this vicious and substantially mendacious partisan political diatribe as an innocent humanitarian appeal has no place in any serious publication, let alone a professional medical journal, and would disgrace even the lowest of the gutter press.” In addition, Pepys accuses Horton personally saying that “Horton’s behavior in this case is consistent with his longstanding and wholly inappropriate use of The Lancet as a vehicle for his own extreme political views. It has greatly detracted from the former high standing of the journal.” In response, Horton said: “How can you separate politics and health? The two go hand-in-hand.”
The following persons have been editors-in-chief of the journal:
- "Prestigious Medical Journal, The Lancet, Issues Family Planning Series". Population Media Center. 13 July 2012. Retrieved 4 March 2014.
- "About the Lancet Medical Journal".
- "The Lancet, About". 7 November 2015.
- 2014 Journal Citation Report Science Edition, Thomson Reuters, 2015.
- 2013 Journal Citation Report Science Edition, Thomson Reuters, 2014.
- The Lancet. Science Direct.
- "Homoeopathy's benefit questioned". BBC News. 26 August 2005.
- Ferriman A (2003). "Lancet calls for tobacco to be made illegal". BMJ. 327 (7428): 1364. doi:10.1136/bmj.327.7428.1364-b.
- What are the Geneva Conventions for?, editorial, The Lancet, vol. 386, no. 10003, p. 1510, 17 October 2015
- Lyall J (2004). "Editor in the eye of a storm". British Medical Journal. 328 (7438): 528. doi:10.1136/bmj.328.7438.528. PMC . PMID 15164721.
- Murch SH, Anthony A, Casson DH, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Valentine A, Davies SE, Walker-Smith JA (March 2004). "Retraction of an interpretation". Lancet. 363 (9411): 750. doi:10.1016/S0140-6736(04)15715-2. PMID 15016483.
- "MMR researchers issue retraction". BBC News. 4 March 2004.
- "Medical journal retracts study linking autism to vaccine". CNN. 2 February 2010.
- Deer, Brian (19 January 2011). "The Lancet's two days to bury bad news". Brian Deer. Retrieved 18 November 2014. "Were it not for the GMC case, which cost a rumored £6m (€7m; $9m), the fraud by which Wakefield concocted fear of MMR would forever have been denied and covered up."
- Laurance, Jeremy (5 December 2003). "Lancet calls for tobacco ban to save thousands of lives". The Independent. Retrieved 18 January 2010.
- "UK ministers urged to ban tobacco". BBC News. 5 December 2003. Retrieved 18 January 2010.
- Coghlan B (30 October 2006). "Gut reaction aside, those on the ground know Iraq reality". Eureka Street.
- Sudbø J, Lee JJ, Lippman SM, et al. (2005). "Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study". The Lancet. 366 (9494): 1359–66. doi:10.1016/S0140-6736(05)67488-0. PMID 16226613. (Retracted)
- "Cancer study patients 'made up'". BBC News. 16 January 2006.
- Hafstad A (17 January 2006). "Største svindel verden har sett". Aftenposten.
- Cortez MF (1 November 2006). "Medical Journal Retracts Oral Cancer Studies Linked to Fraud". Bloomberg.com.
- "Redemption for the Pope?". The Lancet. 373 (9669): 1054. 2009. doi:10.1016/S0140-6736(09)60627-9. PMID 19328984.
- "Radio Vatican article".
- Kumarasamy KK, Toleman MA, Walsh TR, et al. (2010). "Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study". The Lancet Infectious Diseases. 10 (9): 597–602. doi:10.1016/S1473-3099(10)70143-2. PMC . PMID 20705517.
- Yong D, Giske CG, Toleman M, Walsh TR (October 25–28, 2008). "A novel subgroup metallo-B-lactamase (MBL), NDM-1 emerges in Klebsiella pneumoniae (KPN) from India". 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, DC, USA. pp. C1–105.
- Yong D, Toleman MA, Giske CG, et al. (2009). "Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India". Antimicrobial Agents and Chemotherapy. 53 (12): 5046–5054. doi:10.1128/AAC.00774-09. PMC . PMID 19770275.
- MNCs behind superbug propaganda: Ahluwalia - Hindustan Times
- "Researchers dismiss superbug controversy". SIFY News. 14 August 2010. Retrieved 18 November 2014.
- Cheng, Maria (1 November 2010). "Study: Alcohol more lethal than heroin, cocaine". The Boston Globe.
- "Alcohol 'more harmful than heroin' says Prof David Nutt". BBC News. 1 November 2010.
- White PD, et al. (2011). "Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial". The Lancet. 377 (9768): 823–836. doi:10.1016/S0140-6736(11)60096-2. PMID 21334061.
- Sharpe, M; Goldsmith, KA; Johnson, AL; Chalder, T; Walker, J; White, PD (December 2015). "Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial.". The Lancet. Psychiatry. 2 (12): 1067–74. doi:10.1016/s2215-0366(15)00317-x. PMID 26521770.
- David Tuller (21 October 2015). "Trial by Error: The Troubling Case of the PACE Chronic Fatigue Syndrome Study".
- Julie Rehmeyer (13 November 2015). "Hope for Chronic Fatigue Syndrome: The debate over this mysterious disease is suddenly shifting".
- George Faulkner (19 August 2016). "Major breakthrough on PACE trial".
- Julie Rehmeyer and David Tuller (18 March 2017). "Getting It Wrong on Chronic Fatigue Syndrome".
- Wilshire, C; Kindlon, T; Matthees, A; McGrath, S (2016). "Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial". Fatigue: Biomedicine, Health & Behavior. 5 (1). doi:10.1080/21641846.2017.1259724.
- Bleijenberg, G; Knoop, H (2011). "Chronic fatigue syndrome: where to PACE from here?". The Lancet. 377 (9768): 786–788. doi:10.1016/S0140-6736(11)60172-4.
- Manduca, Paolo; et al. "An open letter for the people in Gaza". The Lancet. Retrieved 1 February 2017.
- "Lancet 'hijacked in anti-Israel campaign'". The Telegraph. 22 September 2014. Retrieved 2 October 2014.
- "British medical journal refuses to retract 'letter to Gaza' by anti-Semitic activists". Haaretz. 22 September 2014. Retrieved 2 October 2014.
- Lazareva, Inna (3 October 2014). "Lancet editor apologises for Gaza article by scientists who promoted Ku Klux Klan". The Daily Telegraph. Retrieved 5 October 2014.
- "In Israel, Lancet editor regrets publishing open letter on Gaza". Haaretz. 3 October 2014. Retrieved 5 October 2014.
- Siegel-Itzkovich, Judy (2 October 2014). "The Lancet editor relents on medical journal's unbalanced attacks on Israel". Jerusalem Post. Retrieved 5 October 2014.
- Wallis Simons, Jake (22 September 2014). "Lancet 'hijacked in anti-Israel campaign'". The Daily Telegraph. Retrieved 2 October 2014.